Wednesday, February 27, 2008

The SSRI Delusion

Antidepressants don't work:

Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance ... Drug–placebo differences in antidepressant efficacy increase as a function of baseline severity, but are relatively small even for severely depressed patients. The relationship between initial severity and antidepressant efficacy is attributable to decreased responsiveness to placebo among very severely depressed patients, rather than to increased responsiveness to medication.
Which is to say, taking aspirin or gargling with mouthwash is as effective against depression as those expensive SSRI drugs.

Don't you just love how there is such a thing as "unpublished trial data," and it just happens to be the data that wipes away even the small sliver of possibility that these drugs work? Fabulous.

2 comments:

Zennalathas said...

Well that sure brightened my day...

Dale said...

Happy Times! Great Success!